Effects ofN-Aryl-N ,N -Dialkyl-U-Ethanediainines on ATP Formation in Chloroplasts. QSAR of Amine Uncouplers
نویسنده
چکیده
Arylethanediamines, Photophosphorylation, Uncouplers, Structure-Activity Relationships The effects of the algicide PH 40-62 on photosynthetic reactions in spinach chloroplasts were studied. The compound proved to be an uncoupler of photophosphorylation, whereas inhibition of photosynthetic electron transport occurred at higher concentrations. The site of this inhibition was before photosystem II. The uncoupling effect was partially reversible. In a series of related compounds the uncoupling activity appeared mainly dependent on the lipophilic properties of the compounds but electronic effects also played a distinct role. Comparing these uncoupling data with those of some known series of uncouplers it appeared that lipophilicity determines the uncoupling activity in an identical way and a regression equation was found describing the uncoupling activities of 60 compounds belonging to four chemically different groups of com pounds.
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